Flat-based controlled fed-batch fermentation of the bacterium Photorhabdus luminescens

In this paper, a model based fed-batch strategy for the cultivation of the bacterium Photorhabdus luminescens is proposed. The development of an appropriate trajectory for bacterial growth and substrate feed rate can be obtained using the theory of flat systems introduced by Fliess et al. (1992). To avoid deviations from a desired trajectory caused by model uncertainties or disturbances, a nonlinear controller is presented allowing closed loop control of the fermentation process