Title :
Mapping hippocampal atrophy with a multi-scale model of shape
Author :
Liu, Xinyang ; Shi, Yonggang ; Morra, Jonathan ; Liu Xiuwen ; Thompson, Paul ; Mio, Washington
Author_Institution :
Dept. of Math., Florida State Univ., Tallahasse, FL, USA
fDate :
June 28 2009-July 1 2009
Abstract :
We construct a multi-scale model of shape of surfaces in 3D space based on the heat kernel associated with the Laplace-Beltrami operator. The model is applied to the analysis of longitudinal neuroimaging data collected by the Alzheimer´s Disease Neuroimaging Initiative. We use measures of shape deformation energy to quantify, compare and create maps of regional changes in hippocampal shape in normal aging, progression of Alzheimer´s disease and mild cognitive impairment over a one-year period.
Keywords :
Laplace equations; brain; cognition; diseases; medical image processing; neurophysiology; 3D space; Alzheimer´s disease neuroimaging initiative; Laplace-Beltrami operator; heat kernel; longitudinal neuroimaging data; mapping hippocampal atrophy; mild cognitive impairment; multiscale model; shape deformation energy; time 1 yr; Aging; Alzheimer´s disease; Atrophy; Hippocampus; Kernel; Mathematical model; Mathematics; Neuroimaging; Shape measurement; Space heating; ADNI; Alzheimer´s disease; Shape space; heat kernel; hippocampal atrophy;
Conference_Titel :
Biomedical Imaging: From Nano to Macro, 2009. ISBI '09. IEEE International Symposium on
Conference_Location :
Boston, MA
Print_ISBN :
978-1-4244-3931-7
Electronic_ISBN :
1945-7928
DOI :
10.1109/ISBI.2009.5193193
