Title :
Automatic markup of neural cell membranes using boosted decision stumps
Author :
Venkataraju, Kannan Umadevi ; Paiva, Antonio R C ; Jurrus, Elizabeth ; Tasdizen, Tolga
Author_Institution :
Sch. of Comput., Univ. of Utah, Salt Lake City, UT, USA
fDate :
June 28 2009-July 1 2009
Abstract :
To better understand the central nervous system, neurobiologists need to reconstruct the underlying neural circuitry from electron microscopy images. One of the necessary tasks is to segment the individual neurons. For this purpose, we propose a supervised learning approach to detect the cell membranes. The classifier was trained using AdaBoost, on local and context features. The features were selected to highlight the line characteristics of cell membranes. It is shown that using features from context positions allows for more information to be utilized in the classification. Together with the nonlinear discrimination ability of the AdaBoost classifier, this results in clearly noticeable improvements over previously used methods.
Keywords :
biomembranes; cellular biophysics; feature extraction; image classification; image enhancement; image reconstruction; learning (artificial intelligence); medical image processing; neurophysiology; AdaBoost; boosted decision stumps; central nervous system; electron microscopy; image reconstruction; neural cell membranes; neural circuitry; supervised learning; Biomembranes; Cells (biology); Central nervous system; Circuits; Electron microscopy; Image reconstruction; Image segmentation; Machine learning algorithms; Neurons; Transmission electron microscopy; AdaBoost; Machine Learning; Segmentation; Serial-section TEM; cell membrane detection;
Conference_Titel :
Biomedical Imaging: From Nano to Macro, 2009. ISBI '09. IEEE International Symposium on
Conference_Location :
Boston, MA
Print_ISBN :
978-1-4244-3931-7
Electronic_ISBN :
1945-7928
DOI :
10.1109/ISBI.2009.5193233