DocumentCode
2808329
Title
A method for normalizing histology slides for quantitative analysis
Author
Macenko, Marc ; Niethammer, Marc ; Marron, J.S. ; Borland, David ; Woosley, John T. ; Guan, Xiaojun ; Schmitt, Charles ; Thomas, Nancy E.
Author_Institution
Dept. of Comput. Sci., Univ. of North Carolina, Chapel Hill, NC, USA
fYear
2009
fDate
June 28 2009-July 1 2009
Firstpage
1107
Lastpage
1110
Abstract
Inconsistencies in the preparation of histology slides make it difficult to perform quantitative analysis on their results. In this paper we provide two mechanisms for overcoming many of the known inconsistencies in the staining process, thereby bringing slides that were processed or stored under very different conditions into a common, normalized space to enable improved quantitative analysis.
Keywords
biological tissues; biology computing; biomedical imaging; 24-bit RGB cameras; histology slide normalization; quantitative analysis; Biological cells; Deconvolution; Detectors; Diffraction; Fluorescence; Image retrieval; Information retrieval; Maximum likelihood estimation; Microscopy; Testing; Biomedical image processing; Biomedical microscopy; Biomedical signal detection; Melanoma; Pathology;
fLanguage
English
Publisher
ieee
Conference_Titel
Biomedical Imaging: From Nano to Macro, 2009. ISBI '09. IEEE International Symposium on
Conference_Location
Boston, MA
ISSN
1945-7928
Print_ISBN
978-1-4244-3931-7
Electronic_ISBN
1945-7928
Type
conf
DOI
10.1109/ISBI.2009.5193250
Filename
5193250
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