Advancing biological imaging with multi-spectral optoacoustic tomography (MSOT)

Author

Ntziachristos, V.

Author_Institution

Helmholtz Zentrum Munchen, Tech. Univ. Munchen, Neuherberg, Germany

fYear

2009

fDate

June 28 2009-July 1 2009

Firstpage

1202

Lastpage

1202

Abstract

Multi-spectral optoacoustic tomography (MSOT) is an imaging method that can resolve fluorochromes and other reporter molecules with high sensitivity and specificity deep inside live animals and tissues. The method can penetrate for several millimeters to centimeters in tissues and offers resolutions in the 30 - 100 micron range. We discuss advances with technical implementation and in-vivo imaging applications ranging to imaging various cellular functions in mice. MSOT comes with significant potential to shift the paradigm of biological imaging and become a method of choice in basic and drug discovery and in several clinical applications.

Keywords

acoustic tomography; biological tissues; biomedical optical imaging; cellular biophysics; fluorescence; molecular biophysics; photoacoustic effect; biological imaging; biological tissues; cellular functions; drug discovery; fluorochromes; image resolution; in-vivo imaging applications; live animals; mice; multispectral optoacoustic tomography; reporter molecules; Tomography; fluorescence imaging; molecular imaging; multispectral optoacoustic tomography;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Imaging: From Nano to Macro, 2009. ISBI '09. IEEE International Symposium on

Conference_Location

Boston, MA

ISSN

1945-7928

Print_ISBN

978-1-4244-3931-7

Electronic_ISBN

1945-7928

Type

conf

DOI

10.1109/ISBI.2009.5193276

Filename

5193276