Title :
Advancing biological imaging with multi-spectral optoacoustic tomography (MSOT)
Author :
Ntziachristos, V.
Author_Institution :
Helmholtz Zentrum Munchen, Tech. Univ. Munchen, Neuherberg, Germany
fDate :
June 28 2009-July 1 2009
Abstract :
Multi-spectral optoacoustic tomography (MSOT) is an imaging method that can resolve fluorochromes and other reporter molecules with high sensitivity and specificity deep inside live animals and tissues. The method can penetrate for several millimeters to centimeters in tissues and offers resolutions in the 30 - 100 micron range. We discuss advances with technical implementation and in-vivo imaging applications ranging to imaging various cellular functions in mice. MSOT comes with significant potential to shift the paradigm of biological imaging and become a method of choice in basic and drug discovery and in several clinical applications.
Keywords :
acoustic tomography; biological tissues; biomedical optical imaging; cellular biophysics; fluorescence; molecular biophysics; photoacoustic effect; biological imaging; biological tissues; cellular functions; drug discovery; fluorochromes; image resolution; in-vivo imaging applications; live animals; mice; multispectral optoacoustic tomography; reporter molecules; Tomography; fluorescence imaging; molecular imaging; multispectral optoacoustic tomography;
Conference_Titel :
Biomedical Imaging: From Nano to Macro, 2009. ISBI '09. IEEE International Symposium on
Conference_Location :
Boston, MA
Print_ISBN :
978-1-4244-3931-7
Electronic_ISBN :
1945-7928
DOI :
10.1109/ISBI.2009.5193276
