Computational method to model flow through the mitral valve and early diastolic filling of the left ventricle

Author

Hunt, A.C.

Author_Institution

Musgrove Park Hosp., Taunton, UK

fYear

2000

fDate

2000

Firstpage

223

Lastpage

226

Abstract

This model uses a finite difference Euler equation to recursively calculate the axial midline mitral outlet flow velocity (mfv) from given atrio-ventricular pressure gradients (avpgs). Published data of canine in-vivo avpgs and their mfvs applied to the computer algorithm enabled successful validation. The model simulated 16 early mfvs generated by avpgs produced by different combinations of atrial and left ventricular (lv) loading. The algorithm generated mvf profiles showed the same changes in configuration as observed in in-vivo load altering mfv studies. Index PolyT, derived from a 5th order polynomial in time representing mfvs, showed a 0.99 correlation with the time contstant of IV active relaxation (talc). For taus of 20 and 55 ms, the mean PolyTs were 19.2(SD=0.78)(Cl=18.7-19.7) ms and 54.5 (SD=3.8/(CI=51.8-57.7) ms respectively

Keywords

cardiology; finite difference methods; haemodynamics; physiological models; polynomials; 20 ms; 55 ms; 5th order polynomial; active relaxation; atrioventricular pressure gradients; axial midline mitral outlet flow velocity; canine in-vivo pressure gradients; finite difference Euler equation; haemodynamic modelling; recursive calculation; Acceleration; Computational modeling; Difference equations; Filling; Finite difference methods; Fluid dynamics; Hospitals; Polynomials; Valves; Volume relaxation;

fLanguage

English

Publisher

ieee

Conference_Titel

Computers in Cardiology 2000

Conference_Location

Cambridge, MA

ISSN

0276-6547

Print_ISBN

0-7803-6557-7

Type

conf

DOI

10.1109/CIC.2000.898497

Filename

898497