DocumentCode :
2820689
Title :
DNA Microarray placement for improved performance and reliability
Author :
Kumar, Anurag ; Cho, Minsik ; Pan, David Z.
Author_Institution :
ECE Dept., Univ. of Texas at Austin, Austin, TX, USA
fYear :
2010
fDate :
26-29 April 2010
Firstpage :
275
Lastpage :
278
Abstract :
DNA Microarrays or DNA chips have become a standard method for identification of DNA sequence (genes or gene mutation), determination of abundance of genes and other genomic analysis. DNA Microarrays are composed of small DNA fragments (probes) which are manufactured using masks and photolithographic method similar to VLSI industry. However, photolithographic manufacturing technology introduces errors in the probes due to unintended illumination leading to reduced performance and reliability of the Microarray. In this paper, we present a placement method using a metric for performance of microarray. We propose a Hilbert-curve filling based probe placement which incorporates the performance metric. Experimental results show up to 57× increase in the hybridization potential (leading to higher performance and reliability) of the probes on using our method.
Keywords :
biological techniques; integrated circuit manufacture; integrated circuit reliability; lab-on-a-chip; DNA chips; DNA microarray placement; DNA sequence identification; Hilbert curve filling; probe placement; Bioinformatics; DNA; Filling; Genetic mutations; Genomics; Lighting; Manufacturing industries; Probes; Sequences; Very large scale integration; Placement; microarray;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
VLSI Design Automation and Test (VLSI-DAT), 2010 International Symposium on
Conference_Location :
Hsin Chu
Print_ISBN :
978-1-4244-5269-9
Electronic_ISBN :
978-1-4244-5271-2
Type :
conf
DOI :
10.1109/VDAT.2010.5496742
Filename :
5496742
Link To Document :
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