Enantiomeric separations of neonicotinoid insecticides on a Chirobiotic V column by high-performance liquid chromatography

Author

Li, Weidong

Author_Institution

Coll. of Biol. & Environ. Eng., Zhejiang Univ. of Technol., Hangzhou, China

fYear

2011

fDate

15-17 July 2011

Firstpage

6468

Lastpage

6471

Abstract

The enantiomeric separations of three neonicotinoid insecticides (compounds 1, 2, and 3 ) were performed on a Chirobiotic V chiral column by high-performance liquid chromatography (HPLC) under a new-polar mobile phase mode, using methanol and ethanol with triethylamine as the basic additive as the mobile phase. Compound 1 obtained no separation under all the mobile phase, while compound 2 and 3 were partially separated. Ethanol provides better chiral resolution than methanol, and triethylamine added in ethanol or methanol is in favour of enantiomeric separation for neonicotinoid insecticides. The main chiral recognition mechanism between these three neonicotinoid insecticides and vancomycin CSP might be the hydrogen-bonding interactions, steric interactions and poor ionization interactions.

Keywords

additives; biotechnology; chemical products; chromatography; hydrogen bonds; microorganisms; organic compounds; separation; Chirobiotic V column; additive; chiral recognition; chiral resolution; enantiomeric separations; ethanol; high-performance liquid chromatography; hydrogen-bonding interactions; ionization interactions; methanol; neonicotinoid insecticides; polar mobile phase mode; steric interactions; triethylamine; vancomycin CSP; Antibiotics; Compounds; Educational institutions; Ethanol; Methanol; Mobile communication; Plasmas; HPLC; enantiomeric separation; neonicotinoid;

fLanguage

English

Publisher

ieee

Conference_Titel

Mechanic Automation and Control Engineering (MACE), 2011 Second International Conference on

Conference_Location

Hohhot

Print_ISBN

978-1-4244-9436-1

Type

conf

DOI

10.1109/MACE.2011.5988524

Filename

5988524