A high detection efficiency BGO, flow-through, coincidence detection system for arterial blood sampling with PET: application and dispersion correction for small animal PET studies

Author

Tadokoro, H. ; Yoshida, K. ; Takami, A. ; Shimada, K. ; Kitsukawa, S. ; Suzuki, K. ; Shimizu, K. ; Okada, H.

Author_Institution

Div. of Adv. Technol. for Med. Imaging, Nat. Inst. of Radiol. Sci., Chiba, Japan

Volume

2

fYear

1997

fDate

9-15 Nov 1997

Firstpage

1528

Abstract

A high detection efficiency BGO coincidence detection system has been designed and built for applications to arterial blood sampling in small animals and PET. The detection system uses four BGO detectors in a novel configuration to provide a small central opening with very high sensitivity for insertion of small volume flow-through blood sampling tubing. The performance of the system has been characterized for dead-time losses and randoms. The dispersion function for the flow-through sampling was measured by the step function of concentration and is used to deconvolute the arterial blood concentration. Arterial blood sampling from rabbit PET studies were collected and validated against manual withdrawal of blood samples, and a good correlation was obtained after correction for dispersion function. The system is in routine use with small rabbit preparations for measurement of myocardial blood flow with the Hamamatsu Animal PET system

Keywords

biological techniques; biomedical equipment; blood; positron emission tomography; solid scintillation detectors; Hamamatsu Animal PET system; arterial blood sampling; concentration step function; dead-time losses; dispersion function; flow-through sampling; high detection efficiency BGO coincidence detection system; nuclear medicine; rabbit PET studies; small animals; small volume flow-through blood sampling tubing; Animals; Blood; Detectors; Dispersion; Fluid flow measurement; Myocardium; Performance loss; Positron emission tomography; Rabbits; Sampling methods;

fLanguage

English

Publisher

ieee

Conference_Titel

Nuclear Science Symposium, 1997. IEEE

Conference_Location

Albuquerque, NM

ISSN

1082-3654

Print_ISBN

0-7803-4258-5

Type

conf

DOI

10.1109/NSSMIC.1997.670609

Filename

670609