Modeling Viral and Immune System Dynamics of HBV Infection

Author

Long, Changjiang ; Qi, Huan

fYear

2009

fDate

19-20 Dec. 2009

Firstpage

1

Lastpage

4

Abstract

A mathematical model based on virology, immunology and pathogenesis of hepatitis B virus (HBV) was established to describe the viral and immune system dynamics during HBV infection. The noncytopathic effect of the cellular immune system was set to be proportional to the number of cytotoxic T lymphocytes (CTLs). The condition of being complete recovery (HBV disappeared) was analyzed. Multiple simulations with different parameters were made to show the wide variety of clinical manifestations of HBV infection. The model explains that only a strong immune response can resist HBV infection.

Keywords

cellular biophysics; diseases; microorganisms; HBV infection; cellular immune system; clinical manifestations; cytotoxic T lymphocytes; hepatitis B virus; immune response; immunology; mathematical model; noncytopathic effect; pathogenesis; viral and immune system dynamics; virology; Agricultural engineering; Blood; Educational institutions; Human immunodeficiency virus; Immune system; Liver diseases; Mathematical model; Modeling; Pathogens; Systems engineering and theory;

fLanguage

English

Publisher

ieee

Conference_Titel

Information Engineering and Computer Science, 2009. ICIECS 2009. International Conference on

Conference_Location

Wuhan

Print_ISBN

978-1-4244-4994-1

Type

conf

DOI

10.1109/ICIECS.2009.5363718

Filename

5363718