DocumentCode :
2825991
Title :
Invasive PLA microneedle fabrication applied to drug delivery system
Author :
Kuo, Hsin-Chuan ; Lin, Yi ; Shen, Yung-Kang ; Kang, Sheng-Chieh
Author_Institution :
Dept. of Syst. Eng. & Naval Archit., Nat. Taiwan Ocean Univ., Keelung, Taiwan
fYear :
2011
fDate :
15-17 July 2011
Firstpage :
7437
Lastpage :
7440
Abstract :
This study fabricated a novel biodegradable polymer microneedle patch. First, a master microneedle array was fabricated using the micro electro-mechainal system (MEMS) process. Polydimethylsiloxane (PDMS) was then utilized to fabricate the microneedle mold. Finally, the biodegradable polymer polylactic acid (PLA) microneedle patch was fabricated by micro hot embossing. The Taguchi method was applied to identify the optimal process parameters for micro hot embossing the PLA microneedle. The sizes of the original microneedle and that of the PLA microneedle were compared, through the transfor by PDMS mold. Next, a numerical simulation and the skin puncture test were used to confirm the PLA microneedle patch fabrication using the optimal process parameters. During numerical simulations, this study used dynamic finite element software (ANSYS/LS DYNA) to simulate the process of the PLA microneedle being inserted into skin. Based on the mechanical properties of different skin layers and the material failure criterion, insertion force and stress variation during PLA microneedle insertion into skin were determined. In a skin puncture experiment, transepidermal water loss (TEWL) was measured to determine whether the PLA microneedle damaged the stratum corneum and decreased the water protection capacity of skin.
Keywords :
Taguchi methods; bioMEMS; biodegradable materials; biomedical materials; drug delivery systems; embossing; finite element analysis; medical computing; microfabrication; needles; polymers; skin; ANSYS; LS DYNA; MEMS process; PDMS; PLA microneedle insertion; Taguchi method; biodegradable polymer microneedle patch; biodegradable polymer polylactic acid; drug delivery system; dynamic finite element software; insertion force; invasive PLA microneedle fabrication; master microneedle array; material failure criterion; micro electro-mechainal system; micro hot embossing; microneedle mold; numerical simulation; optimal process parameters; polydimethylsiloxane; skin puncture experiment; skin puncture test; stratum corneum; stress variation; transepidermal water loss; water protection capacity; Arrays; Embossing; Force; Numerical simulation; Programmable logic arrays; Resists; Skin; Micro hot embossing; Numerical simulation; PLA microneedle; Taguchi method; Transepidermal water loss (TEWL);
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Mechanic Automation and Control Engineering (MACE), 2011 Second International Conference on
Conference_Location :
Hohhot
Print_ISBN :
978-1-4244-9436-1
Type :
conf
DOI :
10.1109/MACE.2011.5988769
Filename :
5988769
Link To Document :
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