Title :
A Model for Simulating Action Potential in Ventricular Cell
Author :
Sabzpoushan, S.H. ; Noble, P.J.
Author_Institution :
Dept. of Biomed. Eng., Iran Univ. of Sci. & Technol., Tehran
Abstract :
In this paper we introduce our findings which can lead to a mathematical method for simplifying cell models. In our research we used some well known electro physiologic cardiac cell models and have made observation matrixes from them. With the use of singular value decomposition of the observation matrix, we found that action potential in each examined model can be explained as a linear combination of some other electro physiologic observations. This linear model can be used for simplifying action potential simulation, cardiac cell modelling, tissue modelling and the reduction of computational burden of the simulation of action potential propagation in cardiac tissue.
Keywords :
biological tissues; biology computing; cardiology; cellular biophysics; physiological models; singular value decomposition; action potential propagation; action potential simulation; cardiac cell modelling; cardiac tissue; electrophysiologic cardiac cell model; linear model; observation matrix; singular value decomposition; tissue modelling; ventricular cell; Biological system modeling; Biomedical computing; Cardiac tissue; Computational modeling; Computer simulation; Large-scale systems; Least squares approximation; Mathematical model; Matrix decomposition; Vectors; Action potential simulation; ventricular cell;
Conference_Titel :
Computer Modeling and Simulation, 2008. EMS '08. Second UKSIM European Symposium on
Conference_Location :
Liverpool
Print_ISBN :
978-0-7695-3325-4
Electronic_ISBN :
978-0-7695-3325-4
DOI :
10.1109/EMS.2008.54