A novel approach to the visualization of four-dimensional cerebral angiography with cine angiography data measured at several views

Intracranial arteriovenous malformation (AVM) has a very complex shape, so it is very difficult to decide the targeted region accurately. Intracranial AVM causes convulsion and cerebral hemorrhage, and is therefore a deadly disease. At the present time, as a treatment for AVM, stereotactic radiosurgery is more useful than surgical treatment or chemotherapy. In this radiation therapy, the accuracy of radiosurgical treatment planning for intracranial AVM relies on requiring accurate information of the three dimensional shape and size of the AVM nidus. In conventional radiosurgical treatment planning for intracranial AVM, irradiation fields are determined with dynamic X-ray CT images or angiography of the brain. However, intracranial AVM is complicated in structure, so it is usually very difficult to determine the AVM nidus accurately. The purpose of this study is to clarify the AVM nidus accurately. In order to clarify its region, we proposed a novel method with a cardio-vascular X-ray system with flat panel detector. Our proposed method uses cine angiography measured at several views, and reconstructs a four- dimensional image with these projection data. Also, we tried to reconstruct images with several iterative reconstruction algorithms for transmission tomography. In this paper, we proposed this novel method and showed the validity of our proposed method with some simulations and fundamental experiments.