• DocumentCode
    2852339
  • Title

    A quenched oscillator network for pattern formation in gene expression

  • Author

    Hsia, J. ; Holtz, W.A. ; Huang, D.C. ; Arcak, M. ; Maharbiz, M.M.

  • Author_Institution
    Dept. of Electr. Eng. & Comput. Sci., Univ. of California, Berkeley, CA, USA
  • fYear
    2011
  • fDate
    June 29 2011-July 1 2011
  • Firstpage
    2284
  • Lastpage
    2289
  • Abstract
    Biologists have long searched for reaction net works that can spontaneously generate spatial patterns in the presence of diffusion. The studies so far closely follow Alan Turing\´s "activator-inhibitor" model, where diffusion destabilizes a spatially homogeneous steady state. In this paper, we propose a new type of Turing system based on an oscillator that destabilizes a spatially homogeneous steady state towards a spatio-temporal pattern. We develop a model based on current experimentally-viable systems and study its benefits and limitations.
  • Keywords
    Turing machines; genetics; oscillators; spatiotemporal phenomena; activator-inhibitor model; experimentally-viable systems; gene expression; homogeneous steady state; quenched oscillator network; reaction networks; spatio-temporal pattern; turing system; Additives; Eigenvalues and eigenfunctions; Feedback loop; Jacobian matrices; Oscillators; Pattern formation; Steady-state;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    American Control Conference (ACC), 2011
  • Conference_Location
    San Francisco, CA
  • ISSN
    0743-1619
  • Print_ISBN
    978-1-4577-0080-4
  • Type

    conf

  • DOI
    10.1109/ACC.2011.5991116
  • Filename
    5991116