A novel fingerprint map of SARS-CoV with visualization analysis

Spike (S) protein of severe acute respiratory syndrome coronavirus (SARS-CoV) associates with cellular receptors to mediate infection of their target cells. This paper studies the genome sequences of S protein and SARS ´s receptor based on Z curve method. A visualization characteristic for SARS-CoV has been seized. The comparison results among a large number of genome sequences have proved such characteristic is special for SARS-CoV. Such characteristic can be looked upon as a fingerprint map of SARS-CoV to diagnose a suspected case. Also, this conclusion has been proved in recent real case in Guang Dong, China. Via our study in this paper, we have viewed that: (1) the fingerprint map can provide a nonstandard, simple and visualized detection approach, especially for the situation where the standard method´s results are conflict, and (2) we can take virus and its receptor into coordinated consideration of sequence analysis for SARS-CoV detection.