Abstract :
The influence of different dose-effect functions for lung tissue on the resulting dose distribution was investigated. For a phantom with a L-shaped target, the spinal cord and lung as critical organs, fluence profiles were optimized, subject to a minimum dose constraint for the target, a maximum dose constraint for the spinal cord, and applying different dose-effect functions for the lung. All approaches tested, were capable to control the dose distribution in the lung. The mean dose could not be changed, but the volume of low dose. Due to the simplicity of the functions and parameters, these models are suitable and ready for clinical implementation
Keywords :
Monte Carlo methods; biological tissues; dosimetry; lung; medical computing; physiological models; quadratic programming; radiation therapy; L-shaped target phantom; Monte Carlo kernels; dose response models; dose-effect functions; fluence profiles; intensity modulated radiotherapy; lung tissue; maximum dose constraint; minimum dose constraint; normal tissue; optimisation; pencil beams; sequential quadratic programming; spinal cord; Biological materials; Convolution; Engines; Imaging phantoms; Kernel; Least squares approximation; Lungs; Neutron spin echo; Spinal cord; Testing;
