Title :
A High-Density Magnetoresistive Biosensor Array with Drift-Compensation Mechanism
Author :
Han, Shu-Jen ; Yu, Heng ; Murmann, Boris ; Pourmand, Nader ; Wang, Shan X.
Author_Institution :
Stanford Univ., CA
Abstract :
A DNA microarray of 1008 magnetoresistive sensors employing multidivided array structures for detecting either tow concentration or large-scale gene information is integrated with a 0.25mum BiCMOS chip. The input-referred noise is below 55nV/radicHz. Ionic solution interferences and drifts during biological reaction are removed by applying an in-plane AC magnetic field with two DC field states. Parallel readout is realized by combining FDM with TDM.
Keywords :
BiCMOS integrated circuits; DNA; biology computing; biosensors; compensation; frequency division multiplexing; magnetoresistive devices; microsensors; time division multiplexing; 0.25 micron; BiCMOS chip; DNA microarray; FDM; TDM; drift-compensation mechanism; gene information; in-plane AC magnetic field; magnetoresistive biosensor array; magnetoresistive sensors; multidivided array structures; parallel readout; tow concentration; BiCMOS integrated circuits; Biosensors; DNA; Interference; Large scale integration; Magnetic fields; Magnetic noise; Magnetic sensors; Magnetoresistance; Sensor arrays;
Conference_Titel :
Solid-State Circuits Conference, 2007. ISSCC 2007. Digest of Technical Papers. IEEE International
Conference_Location :
San Francisco, CA
Print_ISBN :
1-4244-0853-9
Electronic_ISBN :
0193-6530
DOI :
10.1109/ISSCC.2007.373347
