The patterning of glutaraldehyde-crosslinked gelatin

This paper proposes a novel technique for fabricating micro patterns of glutaraldehyde(GA)-crosslinked gelatin. It provides another means to crosslink gelatin other than using the photo-sensitizing agents, and the micro patterns of GA-crosslinked gelatin can still be made successfully by accessing the conventional photolithography. The much less toxic and more biocompatible approaches of strengthening the gelatin microstructures can be developed according to the idea herein. The over-crosslinking or the edge-diffusion phenomena, and the correlated processing issues are also depicted in this paper.