Title :
Mechanical response of single living cells by bio-MEMS sensors
Author :
Yang, Shengvuan ; Saif, Taher
Author_Institution :
Dept. of Mech. & Ind. Eng., Illinois Univ., Urbana, IL, USA
Abstract :
The paper presents a new bio-MEMS sensor for insitu force response measurement of single living cells. The sensor consists of fixed-fixed silicon beams connected by a backbone and attached to a probe. The sensor is functionalized by a coating with fibronectin. Adhesion sites are formed between the probe and a single cell by contact. The cell is stretched by the probe and the cell force response is measured from the deflection of the beams and their spring constant. Several living monkey fibroblast cells are tested as they are loaded and unloaded under large deformation. The force response is found to be linear and reversible.
Keywords :
adhesion; biomechanics; biomolecular electronics; biosensors; bone; cellular biophysics; elemental semiconductors; force measurement; microsensors; probes; silicon; Si; adhesion; backbone; bio MEMS sensor; biomicroelectromechanical systems sensor; deformation; fibronectin; force response measurement; living monkey fibroblast cells; mechanical response; probe; silicon beams; single living cells; spring constant; Adhesives; Biosensors; Coatings; Force measurement; Force sensors; Mechanical sensors; Probes; Silicon; Spine; Springs;
Conference_Titel :
Micro Electro Mechanical Systems, 2004. 17th IEEE International Conference on. (MEMS)
Print_ISBN :
0-7803-8265-X
DOI :
10.1109/MEMS.2004.1290573
