Surface enhanced Raman spectra in biochemical molecules and cell detection

Author

Wang, Tsuei-Lian ; Peng, Fang-Ying ; Lu, Hui-Hsin ; Hung, Yung-Ta ; Fang, Tung-Jing ; Chiang, Huihua Kenny

Author_Institution

Inst. of Biomed. Eng., Nat. Yang-Ming Univ., Taipei, Taiwan

fYear

2004

fDate

14-17 Dec. 2004

Firstpage

57

Lastpage

58

Abstract

This work presents the quantitative detection of creatinine molecules and SERS signal from a single cell. Through the utilization of gold nanoparticles, we can measure the lower concentration of specimens. In biochemical molecules analysis, quantification of creatinine in human urine sample is demonstrated. The correlation coefficient can be reached as high as 0.99 for mixture sample, and 0.93 for human subject analysis.

Keywords

biochemistry; biomedical measurement; cellular biophysics; gold; molecular biophysics; nanoparticles; spectrochemical analysis; surface enhanced Raman scattering; Au; SERS; biochemical molecule; cell detection; correlation coefficient; creatinine molecule; gold nanoparticle; human urine sample; quantitative detection; surface enhanced Raman spectra; Band pass filters; Biomedical optical imaging; Gold; Humans; Optical scattering; Optical surface waves; Raman scattering; Rough surfaces; Spectroscopy; Surface roughness;

fLanguage

English

Publisher

ieee

Conference_Titel

Biophotonics, 2004. APBP 2004. The Second Asian and Pacific Rim Symposium on

Print_ISBN

0-7803-8676-0

Type

conf

DOI

10.1109/APBP.2004.1412276

Filename

1412276