Photon migration in a three-dimension human brain model: Monte Carlo simulation

Author

Lee, Cheng-Kuang ; Lee, Hsiang-Chieh ; Sun, Chia-Wei ; Yao, Liang Yu ; Kiang, Yean-Woei ; Yang, C.C.

Author_Institution

Dept. of Electr. Eng., Nat. Taiwan Univ., Taipei, Taiwan

fYear

2004

fDate

14-17 Dec. 2004

Firstpage

59

Lastpage

60

Abstract

In this paper, we demonstrate the time-resolved photon migration phenomena in a 3-D human brain model at variable wavelengths with Monte Carlo simulations. In our simulations, the brain model consists of five layers: scalp, skull, cerebrospinal fluid, gray matter, and white matter. The model imitates the geometry of a real human brain obtained from MRI images. Our simulations can reveal the intensities of photons reaching different layers. We can optimize the source-detector separation in experiments by analyzing the partial intensity variation of the different layers in the brain model.

Keywords

Monte Carlo methods; bio-optics; biomedical MRI; brain models; infrared spectroscopy; source separation; 3-D human brain model; MRI image; Monte Carlo simulation; cerebrospinal fluid; gray matter; partial intensity variation; photon migration; scalp; skull; source-detector separation; three-dimension human brain model; white matter; Absorption; Biomedical optical imaging; Brain modeling; Detectors; Head; Humans; Imaging phantoms; In vivo; Optical propagation; Optical sensors;

fLanguage

English

Publisher

ieee

Conference_Titel

Biophotonics, 2004. APBP 2004. The Second Asian and Pacific Rim Symposium on

Print_ISBN

0-7803-8676-0

Type

conf

DOI

10.1109/APBP.2004.1412277

Filename

1412277