Localized closed-loop temperature control and regulation in hybrid silicon/silicone life science microsystems

Author

Christen, Jennifer Blain ; Andreou, Andreas G. ; Iglehart, Brian

Author_Institution

Electr. & Comput. Eng., Johns Hopkins Univ., Baltimore, MD

fYear

2007

fDate

27-30 May 2007

Firstpage

2886

Lastpage

2889

Abstract

We present hybrid silicon/silicone microsystem for closed-loop temperature control with applications in the life sciences. The system architecture includes an integrated CMOS die for localized thermal cycling and a disposable PDMS microfluidic structure for aseptic fluidic manipulation. Chip design, experimental results and finite element analysis are presented. This work is based on criteria for a clinical diagnostics system comprised of disposable microfluidics for use in tandem with CMOS electronics.

Keywords

CMOS integrated circuits; closed loop systems; finite element analysis; microfluidics; patient diagnosis; temperature control; CMOS electronics; aseptic fluidic manipulation; clinical diagnostics system; disposable PDMS microfluidic structure; finite element analysis; hybrid silicon/silicone life science microsystems; integrated CMOS die; localized closed-loop temperature control; localized thermal cycling; Assembly; DNA; Fabrication; Immune system; Immunity testing; Laboratories; Microfluidics; Protocols; Silicon; Temperature control;

fLanguage

English

Publisher

ieee

Conference_Titel

Circuits and Systems, 2007. ISCAS 2007. IEEE International Symposium on

Conference_Location

New Orleans, LA

Print_ISBN

1-4244-0920-9

Electronic_ISBN

1-4244-0921-7

Type

conf

DOI

10.1109/ISCAS.2007.377852

Filename

4253281