Title :
DNA sequence analysis using fuzzy grammars
Author :
Molina-lozano, Herón ; Vallejo-Clemente, Edgar E. ; Morett-Sánchez, Juna E.
Author_Institution :
Interdiscipl. Prof. Unit of Eng. & Adv. Technol., Nat. Polytech. Inst., Mexico City
Abstract :
We propose to use fuzzy context-free grammars for the analysis of DNA sequences by using the Cocke-Younger-Kasami algorithm to estimate membership grades of a DNA sequence against the language of a fuzzy grammar. As a first example of the application of the proposed method we prove that is possible to determine a fuzzy grammar of a prototype DNA sequence and then found the membership grade of any arbitrary sequence against the specific pattern. As a second example, we formulate a fuzzy grammar from an alignment of promoters by a logo sequence of Escherichia Coli K12 then show how the proposed method can be used for the discovery of regulatory motifs.
Keywords :
biocomputing; fuzzy set theory; grammars; Cocke-Younger-Kasami algorithm; DNA sequence analysis; Escherichia Coli K12; fuzzy context-free grammars; fuzzy grammars; membership grades; regulatory motifs; DNA; Fuzzy systems; Sequences;
Conference_Titel :
Fuzzy Systems, 2008. FUZZ-IEEE 2008. (IEEE World Congress on Computational Intelligence). IEEE International Conference on
Conference_Location :
Hong Kong
Print_ISBN :
978-1-4244-1818-3
Electronic_ISBN :
1098-7584
DOI :
10.1109/FUZZY.2008.4630631