An empirical model of end-tidal CO2 response to minute ventilation

Author

Hahn, Jin-Oh ; Shrawane, Prasad ; Dumont, Guy A. ; Ansermino, J. Mark

Author_Institution

Dept. of Electr. & Comput. Eng., Univ. of British Columbia, Vancouver, BC, Canada

fYear

2010

fDate

Aug. 31 2010-Sept. 4 2010

Firstpage

524

Lastpage

527

Abstract

This paper presents an empirical model of end-tidal CO₂ (P_ETCO₂) response to minute ventilation (MV) for use in the closed-loop control of artificial respiration. An affine model structure consisting of a linear dynamic system followed by an affine transform is presented. It is proposed that this derives a low-order, high-fidelity representation of the respiratory process that can describe the positive and inversely proportional relationship between P_ETCO₂ and MV. The efficacy of the model is evaluated using experimental respiratory data from 18 human subjects. The model performed well with a root-mean-squared error (RMSE) of 0.22+/-0.15mmHg and a coefficient of determination (r²) of 0.81+/-0.18 (mean+/-SD) when a 2^nd-order rational transfer function was used as the linear component of the model. The physiologic implication of the model is analyzed by comparison with a traditional compartment model that is widely used in pharmacological modeling.

Keywords

affine transforms; carbon compounds; closed loop systems; medical control systems; pneumodynamics; ventilation; CO₂; affine transform; artificial respiration; closed-loop control; empirical model; end-tidal CO₂ response; linear dynamic system; low-order high-fidelity representation; minute ventilation; root-mean-squared error; second order rational transfer function; Analytical models; Data models; Lungs; Production; Transfer functions; Transforms; Ventilation; Algorithms; Carbon Dioxide; Child; Databases, Factual; Humans; Least-Squares Analysis; Models, Biological; Respiration, Artificial; Tidal Volume;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society (EMBC), 2010 Annual International Conference of the IEEE

Conference_Location

Buenos Aires

ISSN

1557-170X

Print_ISBN

978-1-4244-4123-5

Type

conf

DOI

10.1109/IEMBS.2010.5626059

Filename

5626059