Closed-loop control of blood glucose level in type-1 diabetics: A simulation study

Survey on diabetes is one of the popular fields of biomedical signal processing. In this paper, a closed-loop system which utilizes modified Stolwijk-Hardy glucose insulin interaction model is considered. The modified model was derived by adding an exogenous insulin infusion term. Two control algorithms are used for exogenous insulin infusion: a Mamdani type fuzzy logic controller (FLC), and a fuzzy-PID controller. Simulations are performed to assess control function in terms of keeping desired steady state plasma glucose level (0.81 mg/ml) against to exogenous glucose input. Simulation results are notable and significant in terms of controlling blood glucose level (BGL). The control algorithms that applied to the model are firstly proposed, therefore this study is made a contribution to the literature.