Title :
Discovery and use of efficient biomarkers for objective disease state assessment in Alzheimer´s disease
Author :
Van Gils, Mark ; Koikkalainen, Juha ; Mattila, Jussi ; Herukka, SannaKaisa ; Lötjönen, Jyrki ; Soininen, Hilkka
Author_Institution :
VTT Tech. Res. Centre of Finland, Tampere, Finland
fDate :
Aug. 31 2010-Sept. 4 2010
Abstract :
Objective and early detection of Alzheimer´s disease (AD) is a demanding problem requiring consideration of manymodal observations. Potentially, many features could be used to discern between people without AD and those at different stages of the disease. Such features include results from cognitive and memory tests, imaging (MRI, PET) results, cerebral spine fluid data, blood markers etc. However, in order to define an efficient and limited set of features that can be employed in classifiers requires mining of data from many patient cases. In this study we used two databases, ADNI and Kuopio LMCI, to investigate the relative importance of features and their combinations. Optimal feature combinations are to be used in a Clinical Decision Support System that is to be used in clinical AD diagnosis practice.
Keywords :
data mining; database management systems; decision support systems; diseases; medical computing; neurophysiology; patient diagnosis; pattern classification; ADNI database; Alzheimer´s disease; Kuopio LMCI database; classifiers; clinical AD diagnosis; clinical decision support system; data mining; efficient biomarker discovery; objective disease state assessment; Biomarkers; Classification algorithms; Databases; Diseases; Heating; Magnetic resonance imaging; Medical diagnostic imaging; Aged; Alzheimer Disease; Apolipoproteins E; Biological Markers; Cerebrospinal Fluid; Cohort Studies; Decision Support Systems, Clinical; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Positron-Emission Tomography; Questionnaires; Reproducibility of Results;
Conference_Titel :
Engineering in Medicine and Biology Society (EMBC), 2010 Annual International Conference of the IEEE
Conference_Location :
Buenos Aires
Print_ISBN :
978-1-4244-4123-5
DOI :
10.1109/IEMBS.2010.5626311