Title :
Manipulation of biological objects in micromachined structures
Author_Institution :
Dept. of Electr. Eng. & Electron., Seikei Univ., Japan
Abstract :
Several methods for the manipulation of biological objects are developed using micromachined structures. The electrostatic effects under high-frequency field, such as dielectrophoresis, electrostatic orientation and electrorotation, are used for the actuation of the objects, by which (1) cell handling, separation, and their fusion, (2) stretching of DNA molecules and their fixation onto substrate, (3) manipulation of protein molecules, and (4) fabrication of membrane structures, etc. are realized. A high-intensity field, in excess of 10 kV/cm, is required for the manipulation of molecules to overcome thermal randomization, which is obtained only with microfabricated electrode gaps
Keywords :
bioelectric phenomena; biological techniques and instruments; cellular biophysics; mechatronics; micromechanical devices; molecular biophysics; AC electric field; cell handling; dielectrophoresis; electrorotation; electrostatic effects; electrostatic orientation; fabrication of membrane structures; high-frequency field; high-intensity field; manipulation of biological objects; manipulation of molecules; manipulation of protein molecules; microfabricated electrode gaps; micromachined structures; stretching of DNA molecules; thermal randomization overcoming; Biomembranes; Chemicals; Electrodes; Electrostatics; Fabrication; Insulation; Optical microscopy; Polarization; Proteins; Voltage;
Conference_Titel :
Micro Electro Mechanical Systems, 1992, MEMS '92, Proceedings. An Investigation of Micro Structures, Sensors, Actuators, Machines and Robot. IEEE
Conference_Location :
Travemunde
Print_ISBN :
0-7803-0497-7
DOI :
10.1109/MEMSYS.1992.187717
