DocumentCode :
2926603
Title :
Application of the HeartLander crawling robot for injection of a thermally sensitive anti-remodeling agent for myocardial infarction therapy
Author :
Chapman, Michael P. ; González, Jose L López ; Goyette, Brina E. ; Fujimoto, Kazuro L. ; Ma, Zuwei ; Wagner, William R. ; Zenati, Marco A. ; Riviere, Cameron N.
Author_Institution :
Heart Lung & Esophageal Surg. Inst., Univ. of Pittsburgh, Pittsburgh, PA, USA
fYear :
2010
fDate :
Aug. 31 2010-Sept. 4 2010
Firstpage :
5428
Lastpage :
5431
Abstract :
The injection of a mechanical bulking agent into the left ventricular (LV) wall of the heart has shown promise as a therapy for maladaptive remodeling of the myocardium after myocardial infarct (MI). The HeartLander robotic crawler presented itself as an ideal vehicle for minimally-invasive, highly accurate epicardial injection of such an agent. Use of the optimal bulking agent, a thermosetting hydrogel developed by our group, presents a number of engineering obstacles, including cooling of the miniaturized injection system while the robot is navigating in the warm environment of a living patient. We present herein a demonstration of an integrated miniature cooling and injection system in the HeartLander crawling robot, that is fully biocompatible and capable of multiple injections of a thermosetting hydrogel into dense animal tissue while the entire system is immersed in a 37°C water bath.
Keywords :
biological tissues; biomedical materials; biomedical measurement; medical robotics; patient treatment; polymer gels; HeartLander crawling robot; animal tissue; biocompatibility; cooling; epicardial injection; living patient; myocardial infarction therapy; optimal bulking agent; temperature 37 degC; thermally sensitive antiremodeling agent; thermosetting hydrogel; warm environment; water bath; Cooling; Foot; Myocardium; Navigation; Needles; Robots; Surgery; Animals; Chickens; Hydrogel; Injections; Motion; Myocardial Infarction; Robotics; Temperature; Ventricular Remodeling;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Engineering in Medicine and Biology Society (EMBC), 2010 Annual International Conference of the IEEE
Conference_Location :
Buenos Aires
ISSN :
1557-170X
Print_ISBN :
978-1-4244-4123-5
Type :
conf
DOI :
10.1109/IEMBS.2010.5626518
Filename :
5626518
Link To Document :
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