Changes of hippocampal CA3-CA1 population nonlinear dynamics across different training sessions in rats performing a memory-dependent task

Author

Chan, Rosa H M ; Song, Dong ; Goonawardena, Anushka V. ; Bough, Sarah ; Sesay, John ; Hampson, Robert E. ; Deadwyler, Sam A. ; Berger, Theodore W.

Author_Institution

Dept. of Biomed. Eng., Univ. of Southern California, Los Angeles, CA, USA

fYear

2010

fDate

Aug. 31 2010-Sept. 4 2010

Firstpage

5464

Lastpage

5467

Abstract

Delayed-nonmatch-to-sample (DNMS) task is memory-dependent. Hippocampal CA3 and CA1 cells were shown to be encoding the required spatial and temporal information to complete this task. In order to identify possible changes in neural population nonlinear dynamics during learning of the DNMS task, we have first modeled the input-output transformation of spike trains across brain subregions from learning animals using a multiple-input, multiple-output (MIMO) nonlinear dynamic model. The feedforward and feedback kernels describing the relations between hippocampal CA3 and CA1 subregions have shown significant changes at different training sessions.

Keywords

brain; cellular biophysics; feedback; feedforward; neurophysiology; nonlinear dynamical systems; physiological models; MIMO; delayed-nonmatch-to-sample task; feedback; feedforward; hippocampal CA3-CA1 population; memory-dependent task; nonlinear dynamics; Animals; Brain modeling; Delay; Hippocampus; Kernel; Nonlinear dynamical systems; Training; Animals; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Feedback, Sensory; Male; Memory; Models, Neurological; Nonlinear Dynamics; Rats; Rats, Long-Evans; Reaction Time; Task Performance and Analysis;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society (EMBC), 2010 Annual International Conference of the IEEE

Conference_Location

Buenos Aires

ISSN

1557-170X

Print_ISBN

978-1-4244-4123-5

Type

conf

DOI

10.1109/IEMBS.2010.5626536

Filename

5626536