Spiral wave induced numerically using electrical stimulation and comparison with experimental results

Author

Xu, Binbin ; Jacquir, Sabir ; Laurent, Gabriel ; Bilbault, Jean-Marie ; Binczak, Stéphane

Author_Institution

Lab. LE2I, Univ. de Bourgogne, Dijon, France

fYear

2010

fDate

Aug. 31 2010-Sept. 4 2010

Firstpage

2650

Lastpage

2653

Abstract

Experiments in vitro on a Microelectrode Array (MEA) platform show that electrical stimulation can provoke the generation of spiral waves in cardiac tissue. Nevertheless, the conditions leading to this artificial fibrillation state remain unclear. In order to have a better understanding of this phenomenon, a numerical simulation study has been conducted. The results obtained with a two-dimensional FitzHugh-Nagumo model proved that it is possible to create spiral waves by adding a stimulation current under certain conditions, which are made explicit.

Keywords

bioelectric phenomena; biological tissues; biomedical electrodes; cardiology; microelectrodes; physiological models; artificial fibrillation state; cardiac tissue model; electrical stimulation; microelectrode array; numerical simulation; spiral waves; stimulation current; two-dimensional FitzHugh-Nagumo model; Arrays; Cardiac tissue; Electrical stimulation; Electrodes; In vitro; Numerical models; Spirals; Action Potentials; Algorithms; Animals; Animals, Newborn; Arrhythmias, Cardiac; Biomedical Engineering; Cells, Cultured; Computer Simulation; Electric Stimulation; Electrodes; Electrophysiology; Heart; Models, Cardiovascular; Models, Statistical; Myocardium; Rats;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society (EMBC), 2010 Annual International Conference of the IEEE

Conference_Location

Buenos Aires

ISSN

1557-170X

Print_ISBN

978-1-4244-4123-5

Type

conf

DOI

10.1109/IEMBS.2010.5626540

Filename

5626540