Myocardial tissue characterization: clinical confirmation of laboratory results

Author

Miller, James G. ; Barzilai, Benico ; Milunski, Mark R. ; Mohr, Gregory A. ; Pérez, Julio E. ; Thomas, Lewis J., III ; Wear, Keith A. ; Wickline, Samuel A. ; Vered, Zvi ; Sobel, Burton E.

Author_Institution

Washington Univ., St. Louis, MO, USA

fYear

1989

fDate

3-6 Oct 1989

Firstpage

1029

Abstract

Tissue characterization previously identified ischemia, infarction, and cardiomyopathy in animal myocardium. Investigations to determine whether analogous results occur in patients were undertaken with a real-time two-dimensional backscatter imaging system. Remote infarction in 15 patients was accompanied by reduced magnitude and delayed cyclic variation. Similarly, ultrasonic evidence of diminished contractile function was found in five patients with dilated cardiomyopathy compared to 15 patients in a control group. Studies of 15 patients with acute myocardial infarction indicate that tissue characterization may permit the detection of reversibly injured or `stunned´ myocardium, despite the presence of severe wall-motion abnormalities that might otherwise mask the presence of viable but transiently dysfunctional tissue

Keywords

acoustic imaging; biomedical ultrasonics; cardiology; patient diagnosis; 2D backscatter imaging; animal myocardium; cardiomyopathy; delayed cyclic variation; infarction; ischemia; medical US imaging; myocardial tissue characterization; patients; severe wall-motion abnormalities; stunned myocardium; transiently dysfunctional tissue; Animals; Attenuation measurement; Backscatter; Cardiology; Laboratories; Myocardium; Pulse measurements; Transfer functions; Ultrasonic imaging; Ultrasonic variables measurement;

fLanguage

English

Publisher

ieee

Conference_Titel

Ultrasonics Symposium, 1989. Proceedings., IEEE 1989

Conference_Location

Montreal, Que.

Type

conf

DOI

10.1109/ULTSYM.1989.67146

Filename

67146