A novel biophysically-detailed mathematical model of rabbit Purkinje cell electrophysiology

Author

Corrias, Alberto ; Rodriguez, Blanca

Author_Institution

Comput. Lab., Univ. of Oxford, Oxford, UK

fYear

2010

fDate

Aug. 31 2010-Sept. 4 2010

Firstpage

2658

Lastpage

2661

Abstract

Purkinje fibres play an important role in cardiac conduction and have been implicated in arrhythmia in presence of diseased states, genetic mutations, or adverse side effects of drugs. For these reasons, the Purkinje assay is commonly used in pre-clinical in vitro drug assessment of arrhythmic risk. Several investigators have pointed out that rabbit Purkinje cells, compared to other species, have a better sensitivity in detecting arrhythmic risk.

Keywords

bioelectric potentials; cardiology; cellular biophysics; diseases; drugs; genetics; physiological models; Purkinje fibres; adverse drugs side effects; arrhythmia; arrhythmic risk detection; biophysically-detailed mathematical model; cardiac conduction; diseased states; genetic mutations; preclinical in vitro drug assessment; rabbit Purkinje cell electrophysiology; Computational modeling; Drugs; Heart; Mathematical model; Predictive models; Rabbits; Sensitivity analysis; Action Potentials; Animals; Arrhythmias, Cardiac; Biophysics; Computer Simulation; Electrophysiology; Imaging, Three-Dimensional; Models, Cardiovascular; Models, Theoretical; Purkinje Cells; Rabbits; Risk; Sodium-Potassium-Exchanging ATPase; Software;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society (EMBC), 2010 Annual International Conference of the IEEE

Conference_Location

Buenos Aires

ISSN

1557-170X

Print_ISBN

978-1-4244-4123-5

Type

conf

DOI

10.1109/IEMBS.2010.5626614

Filename

5626614