Title :
A novel biophysically-detailed mathematical model of rabbit Purkinje cell electrophysiology
Author :
Corrias, Alberto ; Rodriguez, Blanca
Author_Institution :
Comput. Lab., Univ. of Oxford, Oxford, UK
fDate :
Aug. 31 2010-Sept. 4 2010
Abstract :
Purkinje fibres play an important role in cardiac conduction and have been implicated in arrhythmia in presence of diseased states, genetic mutations, or adverse side effects of drugs. For these reasons, the Purkinje assay is commonly used in pre-clinical in vitro drug assessment of arrhythmic risk. Several investigators have pointed out that rabbit Purkinje cells, compared to other species, have a better sensitivity in detecting arrhythmic risk.
Keywords :
bioelectric potentials; cardiology; cellular biophysics; diseases; drugs; genetics; physiological models; Purkinje fibres; adverse drugs side effects; arrhythmia; arrhythmic risk detection; biophysically-detailed mathematical model; cardiac conduction; diseased states; genetic mutations; preclinical in vitro drug assessment; rabbit Purkinje cell electrophysiology; Computational modeling; Drugs; Heart; Mathematical model; Predictive models; Rabbits; Sensitivity analysis; Action Potentials; Animals; Arrhythmias, Cardiac; Biophysics; Computer Simulation; Electrophysiology; Imaging, Three-Dimensional; Models, Cardiovascular; Models, Theoretical; Purkinje Cells; Rabbits; Risk; Sodium-Potassium-Exchanging ATPase; Software;
Conference_Titel :
Engineering in Medicine and Biology Society (EMBC), 2010 Annual International Conference of the IEEE
Conference_Location :
Buenos Aires
Print_ISBN :
978-1-4244-4123-5
DOI :
10.1109/IEMBS.2010.5626614
