Title :
Silicon nanowires for bioadhesive drug delivery
Author :
Fischer, K. ; Tao, Sarah ; Daniels, Hugh ; Li, Edward ; Desai, Tejal
Author_Institution :
Univ. of California San Francisco, San Francisco, CA
Abstract :
A technique to coat three dimensional surfaces with silicon nanowires was used to create test devices to characterize the adhesion of microspheres to a model of the human intestine with the end goal of increasing bioavailability in drug delivery. Results indicate negligible toxicity and significant improvements in adhesion over conventional technologies.
Keywords :
adhesion; coatings; drug delivery systems; elemental semiconductors; silicon; surface treatment; adhesion; bioadhesive drug delivery; bioavailability; human intestine; microspheres; silicon nanowires; three dimensional surfaces; Adhesives; Chemicals; Coatings; Drug delivery; In vitro; Nanowires; Polymers; Silicon; Surface topography; Testing;
Conference_Titel :
Electron Devices Meeting, 2008. IEDM 2008. IEEE International
Conference_Location :
San Francisco, CA
Print_ISBN :
978-1-4244-2377-4
Electronic_ISBN :
8164-2284
DOI :
10.1109/IEDM.2008.4796686
