A generic ionic model of cardiac action potentials

Author

Guo, Tianruo ; Abed, Amr Al ; Lovell, Nigel H. ; Dokos, Socrates

Author_Institution

Grad. Sch. of Biomed. Eng., Univ. of New South Wales, Sydney, NSW, Australia

fYear

2010

fDate

Aug. 31 2010-Sept. 4 2010

Firstpage

1465

Lastpage

1468

Abstract

A generic cardiac ionic model employing membrane currents based on two-gate Hodgkin-Huxley kinetics is presented. Its generic nature allows it to accurately reproduce action potential waveforms in heterogeneous cardiac tissue by optimizing parameters governing ion channel kinetics and magnitudes. The model allows a user-defined number of voltage and time-dependent ion currents to be incorporated, in order to reproduce and predict electrophysiological action potential waveforms from multiple recordings in individual cardiac myocytes.

Keywords

bioelectric potentials; biological tissues; biomembrane transport; cardiology; medical signal processing; optimisation; physiological models; cardiac action potentials; cardiac myocytes; electrophysiological action potential waveforms; generic ionic model; heterogeneous cardiac tissue; ion channel kinetics; membrane currents; optimization; time-dependent ion currents; two-gate Hodgkin-Huxley kinetics; Biomembranes; Computational modeling; Heart; Markov processes; Mathematical model; Rabbits; Storage area networks; Action Potentials; Animals; Cells, Cultured; Computer Simulation; Heart Conduction System; Ion Channel Gating; Membrane Potentials; Models, Cardiovascular; Myocytes, Cardiac; Rabbits;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society (EMBC), 2010 Annual International Conference of the IEEE

Conference_Location

Buenos Aires

ISSN

1557-170X

Print_ISBN

978-1-4244-4123-5

Type

conf

DOI

10.1109/IEMBS.2010.5626853

Filename

5626853