Title :
Differential stimulation of ON and OFF retinal ganglion cells: A modeling study
Author :
Kameneva, Tatiana ; Meffin, Hamish ; Burkitt, Anthony N.
Author_Institution :
Dept. of Electr. Eng., Univ. of Melbourn, Melbourn, VIC, Australia
fDate :
Aug. 31 2010-Sept. 4 2010
Abstract :
A model of the electrophysiological properties of ON and OFF retinal ganglion cells (RGCs) was constrained and validated using experimental data from the literature. Our simulations support experimental findings that differences in the magnitude of the T-type Ca2+ current explain differences in the intrinsic electrophysiology of ON and OFF RGCs. The models are used to investigate the potential for differential stimulation of ON and OFF RGCs during neuroprosthetic stimulation with sinusoidal current. The model predicts that OFF cells fire preferential over ON cells in a frequency band around 10 Hz.
Keywords :
bioelectric phenomena; cellular biophysics; eye; neurophysiology; RGC; T-type Ca2+ current; electrophysiological properties model; neuroprosthetic stimulation; off retinal ganglion cell; on retinal ganglion cell; retinal ganglion cell differential stimulation; sinusoidal current; Biomembranes; Data models; Electrical stimulation; Mathematical model; Neurons; Prosthetics; Retina; Animals; Calcium Channels, T-Type; Humans; Models, Biological; Patch-Clamp Techniques; Retinal Ganglion Cells;
Conference_Titel :
Engineering in Medicine and Biology Society (EMBC), 2010 Annual International Conference of the IEEE
Conference_Location :
Buenos Aires
Print_ISBN :
978-1-4244-4123-5
DOI :
10.1109/IEMBS.2010.5627176
