High frequency wideband permittivity measurements of biological substances using coplanar waveguides and application to cell suspensions

Author

Seo, Sanghyun ; Stintzing, Thomas ; Block, Ian ; Pavlidis, Dimitris ; Rieke, Matthias ; Layer, Paul G.

Author_Institution

Department of High Frequency Electronics, Darmstadt University of Technology, D-64283, Germany

fYear

2008

fDate

15-20 June 2008

Firstpage

915

Lastpage

918

Abstract

Complex permittivity measurements of liquids and living cell suspensions with finite ground coplanar waveguides (FG-CPW) in a SU-8 reservoir are presented. A simple de-embedding method based on ABCD matrices is described. Complex permittivity measurements of reference liquids such as methanol and isopropanol show good agreement with theoretical values. Results on living cell suspensions (human embryonic kidney cells) measured over the frequency range of 1 to 32 GHz are described. Dimethylsulfoxide (DMSO) toxicity tests on cell suspension show time dependent permittivity changes due to cell disintegration and diffusion process.

Keywords

biomedical measurement; biomedical transducers; coplanar waveguides; microwave measurement; permittivity measurement; ABCD matrices; biological substances; cell disintegration; de-embedding method; diffusion process; dimethylsulfoxide toxicity tests; finite ground coplanar waveguides; frequency 1 GHz to 32 GHz; high frequency wideband permittivity measurements; human embryonic kidney cells; isopropanol; living cell suspensions; methanol; Cells (biology); Coplanar waveguides; Frequency; Liquid waveguides; Methanol; Permittivity measurement; Reservoirs; Suspensions; Transmission line matrix methods; Wideband; Biological cells; Biomedical transducers; Coplanar waveguides; Permittivity; Permittivity measurement;

fLanguage

English

Publisher

ieee

Conference_Titel

Microwave Symposium Digest, 2008 IEEE MTT-S International

Conference_Location

Atlanta, GA

ISSN

0149-645X

Print_ISBN

978-1-4244-1780-3

Electronic_ISBN

0149-645X

Type

conf

DOI

10.1109/MWSYM.2008.4632982

Filename

4632982