DocumentCode :
2946416
Title :
Discrete cortical responses from multi-site supra-choroidal electrical stimulation in the feline retina
Author :
Suaning, G.J. ; Kisban, S. ; Chen, S.C. ; Byrnes-Preston, P.J. ; Dodds, C. ; Tsai, D. ; Matteucci, P. ; Herwik, S. ; Morley, J.W. ; Lovell, N.H. ; Paul, O. ; Stieglitz, T. ; Ruther, P.
Author_Institution :
Grad. Sch. of Biomed. Eng., Univ. of New South Wales, Sydney, NSW, Australia
fYear :
2010
fDate :
Aug. 31 2010-Sept. 4 2010
Firstpage :
5879
Lastpage :
5882
Abstract :
Exploration into electrical stimulation of the retina has thus far focussed primarily upon the development of prostheses targeted at one of two sites of intervention - the epi- and sub-retinal surfaces. These two approaches have sound, logical merit owing to their proximity to retinal neurons and their potential to deliver stimuli via the surviving retinal neural networks respectively. There is increasing evidence, however, that electric field effects, electrode engineering limitations, and electrode-tissue interactions limit the spatial resolution that once was hoped could be elicited from electrical stimulation at epi- and sub-retinal sites. An alternative approach has been proposed that places a stimulating electrode array within the supra-choroidal space - that is, between the sclera and the choroid. Here we investigate whether discrete, cortical activity patterns can be elicited via electrical stimulation of a feline retina using a custom, 14 channel, silicone rubber and Pt electrode array arranged in two hexagons comprising seven electrodes each. Cortical responses from Areas 17/18 were acquired using a silicon-based, multi-channel, penetrating probe developed at IMTEK, University of Freiburg, within the European research project NeuroProbes. Multi-unit spike activity was recorded in synchrony with the presentation of electrical stimuli. Results show that distinct cortical response patterns could be elicited from each hexagon separated by 1.8 mm (center-to-center) with a center-to-center electrode spacing within each hexagon of 0.55 mm. This lends support that higher spatial resolution may also be discerned.
Keywords :
bioelectric potentials; biological tissues; biomedical electrodes; eye; medical signal processing; neurophysiology; prosthetics; choroid; cortical activity patterns; discrete cortical responses; electric field effects; electrode engineering limitations; electrode-tissue interactions; epiretinal surface; feline retina; multisite suprachoroidal electrical stimulation; multiunit spike activity; neural networks; neurons; prostheses; sclera; spatial resolution; stimulating electrode array; subretinal surface; suprachoroidal space; Animals; Arrays; Electric potential; Electrodes; Probes; Retina; Visualization; Action Potentials; Animals; Cats; Cerebral Cortex; Choroid; Electric Stimulation; Electrodes; Evoked Potentials, Visual; Microtechnology; Neurons; Retina;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Engineering in Medicine and Biology Society (EMBC), 2010 Annual International Conference of the IEEE
Conference_Location :
Buenos Aires
ISSN :
1557-170X
Print_ISBN :
978-1-4244-4123-5
Type :
conf
DOI :
10.1109/IEMBS.2010.5627527
Filename :
5627527
Link To Document :
بازگشت