Sugar coated stealth carbon nanotubes

Author

Kotagiri, Nalinikanth ; Kim, Jin-woo

Author_Institution

Bio/Nano Technol. Lab., Univ. of Arkansas, Fayetteville, AR, USA

fYear

2010

fDate

5-9 Dec. 2010

Firstpage

102

Lastpage

107

Abstract

Single walled carbon nanotubes (SWNT) have shown tremendous promise as agents for diagnostic and therapeutic intervention in vivo. We demonstrate how Dextran sulfate (DS) can render SWNT transparent to macrophages, a vital component of the innate immunity. We also demonstrate a site specific attachment strategy to conjugate antibodies to DS for downstream applications. DS was compared to Polyethylene Glycol (PEG) coated SWNT, a trusted standard for rendering nanoparticles immune to opsonization.

Keywords

biomedical materials; carbon nanotubes; microorganisms; nanobiotechnology; nanoparticles; patient diagnosis; patient treatment; polymers; sugar; Dextran sulfate; PEG coated SWNT; conjugate antibodies; diagnostic agents; innate immunity; macrophages; nanoparticles; opsonization; polyethylene glycol; single walled carbon nanotubes; site specific attachment strategy; sugar coated stealth carbon nanotube; therapeutic intervention; Decision support systems; Fluorescence; Immune system; In vivo; Microscopy; Nanoparticles; Plastics; Dextran sulfate; Macrophage; Opsonization; Polyethylene Glycol; Single walled Carbon Nanotubes;

fLanguage

English

Publisher

ieee

Conference_Titel

Nano/Molecular Medicine and Engineering (NANOMED), 2010 IEEE 4th International Conference on

Conference_Location

Hong Kong/Macau

ISSN

2159-6964

Print_ISBN

978-1-61284-152-6

Type

conf

DOI

10.1109/NANOMED.2010.5749813

Filename

5749813