Title :
Sugar coated stealth carbon nanotubes
Author :
Kotagiri, Nalinikanth ; Kim, Jin-woo
Author_Institution :
Bio/Nano Technol. Lab., Univ. of Arkansas, Fayetteville, AR, USA
Abstract :
Single walled carbon nanotubes (SWNT) have shown tremendous promise as agents for diagnostic and therapeutic intervention in vivo. We demonstrate how Dextran sulfate (DS) can render SWNT transparent to macrophages, a vital component of the innate immunity. We also demonstrate a site specific attachment strategy to conjugate antibodies to DS for downstream applications. DS was compared to Polyethylene Glycol (PEG) coated SWNT, a trusted standard for rendering nanoparticles immune to opsonization.
Keywords :
biomedical materials; carbon nanotubes; microorganisms; nanobiotechnology; nanoparticles; patient diagnosis; patient treatment; polymers; sugar; Dextran sulfate; PEG coated SWNT; conjugate antibodies; diagnostic agents; innate immunity; macrophages; nanoparticles; opsonization; polyethylene glycol; single walled carbon nanotubes; site specific attachment strategy; sugar coated stealth carbon nanotube; therapeutic intervention; Decision support systems; Fluorescence; Immune system; In vivo; Microscopy; Nanoparticles; Plastics; Dextran sulfate; Macrophage; Opsonization; Polyethylene Glycol; Single walled Carbon Nanotubes;
Conference_Titel :
Nano/Molecular Medicine and Engineering (NANOMED), 2010 IEEE 4th International Conference on
Conference_Location :
Hong Kong/Macau
Print_ISBN :
978-1-61284-152-6
DOI :
10.1109/NANOMED.2010.5749813
