Super paramagnetic nanoparticles delivery through a microcatheter by solenoids

Author

Nguyen, Yann ; Miroir, Mathieu ; Kazmitcheff, Guillaume ; Ferrary, Evelyne ; Sterkers, Olivier ; Grayeli, Alexis Bozorg

Author_Institution

Inserm, Univ. Paris 7 Denis Diderot, Paris, France

fYear

2010

fDate

5-9 Dec. 2010

Firstpage

153

Lastpage

157

Abstract

In order to design a drug delivery system to the human cochlea, a magnetic pump driving Fe₃O₄ super paramagnetic nanoparticles (MNP) attachable to a drug was evaluated. Such a device could be inserted into the cochlea by a minimally invasive technique. In this study, the effect of a magnetic field generated by solenoids coiled around a 1 mm diameter catheter filled with 200 nm MNP was studied. Results showed that, particles can be concentrated at different locations of the catheter for a precise delivery at different cochlear locations. The particles could also be driven between 2 solenoids 50 mm apart with 150 mA which is compatible with current sources in available cochlear implants.

Keywords

biomagnetism; cochlear implants; drug delivery systems; ear; iron compounds; magnetic particles; nanomedicine; nanoparticles; solenoids; superparamagnetism; Fe₃O₄; cochlear implant; drug delivery system; human cochlea; magnetic pump; microcatheter; minimally invasive technique; solenoid; super paramagnetic nanoparticles delivery; Catheters; Coils; Drugs; Ear; Magnetic resonance imaging; Nanoparticles; Solenoids;

fLanguage

English

Publisher

ieee

Conference_Titel

Nano/Molecular Medicine and Engineering (NANOMED), 2010 IEEE 4th International Conference on

Conference_Location

Hong Kong/Macau

ISSN

2159-6964

Print_ISBN

978-1-61284-152-6

Type

conf

DOI

10.1109/NANOMED.2010.5749824

Filename

5749824