Incorporating biologic tissue data into a computer model of myocardium: effects of heterogeneous sympathetic innervation on dispersion of repolarization

Author

Wagner, Mary B. ; Dae, Michael W. ; Lesh, Michael D.

Author_Institution

Bioeng. Graduate Group, California Univ., Berkeley, CA, USA

Volume

1

fYear

1995

fDate

20-25 Sep 1995

Firstpage

29

Abstract

It has been suggested that heterogeneous sympathetic innervation may be involved in the development of ventricular tachycardia (VT). The authors incorporated imaging data of heterogeneous sympathetic innervation in dogs into a model a thin sheet of myocardium and showed that dispersion of repolarization (which may form part of the substrate for VT) increases with increasing heterogeneity of innervation and increasing coupling resistivity

Keywords

bioelectric phenomena; biology computing; cardiology; digital simulation; muscle; neurophysiology; physiological models; biologic tissue data incorporation; cardiac electrophysiology; coupling resistivity; dogs; heterogeneous sympathetic innervation effects; innervation heterogeneity; myocardium computer model; repolarization dispersion; ventricular tachycardia development; Biological system modeling; Biological tissues; Biology computing; Conductivity; Dispersion; Dogs; Heart; Myocardium; Nearest neighbor searches; Nerve endings;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 1995., IEEE 17th Annual Conference

Conference_Location

Montreal, Que.

Print_ISBN

0-7803-2475-7

Type

conf

DOI

10.1109/IEMBS.1995.574984

Filename

574984