Influences of sites and protocols on inducing ventricular fibrillation: A computer simulation study

In cardiac electrophysiological study, several electrical stimulation protocols have been employed to induce ventricular fibrillations (VF). In addition, sites of inducing may have different impacts on inducing results as well as different inducing protocols. To study whether VF inducing method is determinant of induced outcome, we simulated VFs induced with different protocols at different sites based on the Wei-Harumi whole heart model. Simulations showed that only certain combinations of pacing protocols and sites could induce sustainable VFs, which had similar frequency distributions. This result suggested that the interactions between protocols and sites determine the odds of successful inducing but once the VF was induced, the pattern was solely determined by inner cardiac properties.