Title :
SWISS-TANDEM: A Web-Based Workspace for MS/MS Protein Identification on PC Grids
Author :
Zosso, Dominique ; Arnold, Konstantin ; Schwede, Torsten ; Podvinec, Michael
Author_Institution :
Univ. of Basel, Basel
Abstract :
Tandem mass spectrometry is a powerful technique for the identification of proteins contained in a biological sample. We present a grid-based application service for the analysis of tandem mass spectra, based on the open-source X/Tandem algorithm. The implemented parallelization strategy allows the distribution of analysis jobs to a grid of desktop PCs, utilizing their idle capacity. For this application service, a user-friendly project-oriented frontend was developed, implemented as a Web-based workspace. After analysis, results are visualized and presented to the user along with a set of powerful and novel tools to allow further interpretation and evaluation of search results.
Keywords :
Internet; biochemistry; biology computing; data visualisation; grid computing; human computer interaction; mass spectra; mass spectroscopy; molecular biophysics; online front-ends; parallel processing; proteins; public domain software; PC grids; SWISS-TANDEM; Web-based workspace; biological sample; data visualisation; grid-based application service; open-source X-Tandem algorithm; parallelization strategy; protein identification; tandem mass spectrometry; user-friendly project-oriented front ends; Algorithm design and analysis; Concurrent computing; Databases; Grid computing; Mass spectroscopy; Peptides; Personal communication networks; Proteins; Proteomics; Visualization;
Conference_Titel :
Computer-Based Medical Systems, 2007. CBMS '07. Twentieth IEEE International Symposium on
Conference_Location :
Maribor
Print_ISBN :
0-7695-2905-4
DOI :
10.1109/CBMS.2007.103
