Title :
A compact, nano-power CMOS action potential detector
Author :
Hiseni, Senad ; Sawigun, Chutham ; Ngamkham, Wannaya ; Serdijn, Wouter A.
Author_Institution :
Biomed. Electron. Group, Delft Univ. of Technol., Delft, Netherlands
Abstract :
Real time action potential (AP) detection is an important requirement for development of fully implantable neuroprosthetic devices. We present an ultra low-power CMOS analog circuit for detection of APs embedded in a noisy signal. The proposed strategy isolates APs by detecting subsequently a positive and a negative spike of each AP. An AP is detected only if the positive spike is detected within a short period of time after the negative spike was detected. The proposed circuit has been designed to be implemented in AMIS 0.35 ¿m technology (I3T80) and has been verified in Cadence using RF spectre. The final circuit operates from a 1-V supply and consumes only 1.5 nA. The detector is verified by means of simulations with synthetic neural waveforms and is able to successfully detect APs in noisy signals.
Keywords :
CMOS analogue integrated circuits; bioelectric phenomena; biomedical electronics; low-power electronics; medical signal detection; neurophysiology; prosthetics; AMIS technology; I3T80; action potential negative spike; action potential positive spike; compact nanopower CMOS action potential detector; current 1.5 nA; implantable neuroprosthetic devices; noisy signal embedded AP; real time action potential detection; synthetic neural waveforms; ultra low-power CMOS analog circuit; voltage 1 V; CMOS technology; Circuit noise; Circuit simulation; Detectors; Energy consumption; Frequency estimation; Integrated circuit technology; Isolation technology; Neural prosthesis; Neurons; CMOS; action potential detector; analog integrated circuits; biomedical signal processing; extracellular recordings; low-voltage; multichannel recordings; prosthetic devices; ultra low-power;
Conference_Titel :
Biomedical Circuits and Systems Conference, 2009. BioCAS 2009. IEEE
Conference_Location :
Beijing
Print_ISBN :
978-1-4244-4917-0
Electronic_ISBN :
978-1-4244-4918-7
DOI :
10.1109/BIOCAS.2009.5372074
