Title :
A CMOS sensor for in-vivo fluorescence and electrical imaging in a mouse brain
Author :
Sasagawa, Kiyotaka ; Tagawa, Ayato ; Minami, Hiroki ; Mitani, Masahiro ; Noda, Toshihiko ; Tokuda, Takashi ; Tamura, Hideki ; Hatanaka, Yumiko ; Ishikawa, Yasuyuki ; Shiosaka, Sadao ; Ohta, Jun
Author_Institution :
Grad. Sch. of Mater. Sci., Nara Inst. of Sci. & Technol., Ikoma, Japan
Abstract :
We report a complementary-metal-oxide-semiconductor (CMOS) image sensor for in-vivo imaging. The sensor is implemented on a flexible substrate with LEDs as excitation light sources. The images are successfully obtained in a mouse brain. We demonstrate a image contrast improvement method on the basis of image processing and multiple readout in order to overcome non uniform illumination of the excitation light.
Keywords :
CMOS image sensors; bioelectric potentials; biomedical optical imaging; brain; fluorescence; CMOS image sensor; CMOS sensor; LED; electrical imaging; flexible substrate; image contrast improvement method; in-vivo fluorescence; mouse brain; Brain; CMOS image sensors; Fluorescence; High-resolution imaging; Image sensors; Light emitting diodes; Magnetic resonance imaging; Materials science and technology; Mice; Sensor arrays;
Conference_Titel :
Biomedical Circuits and Systems Conference, 2009. BioCAS 2009. IEEE
Conference_Location :
Beijing
Print_ISBN :
978-1-4244-4917-0
Electronic_ISBN :
978-1-4244-4918-7
DOI :
10.1109/BIOCAS.2009.5372089
