Computer simulations of shunt performance in hydrocephalus

Author

Ahearn, E. ; Randall, K. ; Cipolletti, G. ; Johnson, R.

Author_Institution

Dept. of Biomed. Eng., North Carolina Univ., Chapel Hill, NC, USA

fYear

1988

fDate

10-11 Mar 1988

Firstpage

194

Lastpage

197

Abstract

A five-compartment mathematical model of the cerebrospinal fluid (CSF) system has been developed to allow analysis of system control mechanisms, to aid in the understanding of the pathogenesis of hydrocephalus, and to facilitate the design of shunt device to treat this disorder. The CSF system is model using a five-compartment electric circuit analog, which divides the CSF flow pathway into the four ventricles and the subarachnoid space. The model incorporates the pressure-sensitive elements of the CSF flow system, which include ventricular compliance, outflow resistance, and CSF formation. In addition, age-dependent relationships that further characterize the pressure-volume index and the CSF formation rate are included in the model

Keywords

biological fluid dynamics; brain models; digital simulation; physiological models; 5-compartment mathematical model; cerebrospinal fluid system; computer simulation; electric circuit analog; hydrocephalus; outflow resistance; pathogenesis; pressure-sensitive elements; pressure-volume index; shunt performance; subarachnoid space; system control mechanisms; ventricles; ventricular compliance; Catheters; Circuits; Computational modeling; Computer simulation; Electric resistance; Encoding; Equations; Feedback; Immune system; Valves;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioengineering Conference, 1988., Proceedings of the 1988 Fourteenth Annual Northeast

Conference_Location

Durham, NH

Type

conf

DOI

10.1109/NEBC.1988.19382

Filename

19382