Title :
Organophosphonate-induced toxicity: computer study of reentry in atrial tissue
Author :
Zoltani, CK ; Baskin, SI
Author_Institution :
US Army Res. Lab., Aberdeen Proving Ground, MD, USA
Abstract :
The electrophysiologic changes of organophosphonate (OP)-produced acetylcholine (ACh) overload in atrial tissue was studied by computer simulation. Changes in the action potential dynamics due to the heterogeneity of the substrate resulting from OP deposition in the tissue were produced, and the conditions for the generation and persistence of reentry waves were determined. It was shown that modulation of cardiac cell membrane currents can be used to modulate conditions leading to reentry suggesting avenues to prophylaxis.
Keywords :
cardiology; digital simulation; medical computing; action potential dynamics; atrial tissue; cardiac cell membrane currents; computer simulation; electrophysiologic changes; organophosphonate-produced acetylcholine overload; prophylaxis; reentry waves; Atrial fibrillation; Biomembranes; Calcium; Cardiology; Cells (biology); Chemicals; Computer simulation; Extracellular; Laboratories; Military computing;
Conference_Titel :
Computers in Cardiology, 2002
Print_ISBN :
0-7803-7735-4
DOI :
10.1109/CIC.2002.1166821
