Title :
Mesenchymal stem cell differentiation by nano-engineered Si columns
Author :
Trabzon, Levent ; Ramazanoglu, Mustafa ; Kizil, Huseyin ; Güvendik, Sebahattin
Author_Institution :
Dept. of Mech. Eng., Istanbul Tech. Univ., Istanbul, Turkey
Abstract :
We successfully engineered Si nano-columns with different cross-sectional geometries by e-beam evaporation with an angle between source and substrate. The Si nano-columns were grown as pillars with square, triangle and linear cross sections in in-plane. Mesenchymal stem cells (MSCs) isolated from the bone marrow stroma of young adult rats were cultured on these different Si nanosurfaces. We found that the behaviour of MSCs highly depended on the geometry of nano-topography so that mesenchymal stem cells were differentiated and induced CaP precipitation on square-cross-sectional Si nano-columns without growth factor in the culture medium.
Keywords :
biomedical materials; cellular biophysics; electron beam deposition; evaporation; nanobiotechnology; silicon; Si; bone marrow stroma; cross-sectional geometry; e-beam evaporation; mesenchymal stem cell differentiation; nanoengineered silicon column; nanotopography; Cells (biology); Silicon; Stem cells; Substrates; Surface morphology; Surface topography; Biomaterials; Nano-Columns; Stem Cells;
Conference_Titel :
Biomedical Engineering (MECBME), 2011 1st Middle East Conference on
Conference_Location :
Sharjah
Print_ISBN :
978-1-4244-6998-7
DOI :
10.1109/MECBME.2011.5752061