Title :
A CMOS-Compatible Optical Biosensing System Based on Visible Absorption Spectroscopy
Author :
Chang, Yu-Wei ; Yu, Ping-Chun ; Huang, Yang-Tung ; Yang, Yuh-Shyong
Author_Institution :
Nat. Chiao Tung Univ., Hsinchu
Abstract :
A CMOS-compatible optical biosensing system based on visible absorption spectroscopy is proposed. Within the compact prototype, the CMOS sensor consisting a P+/Nwell finger photodiode and a transimpedance amplifier (TIA) is implemented in a standard 0.35-mum CMOS technology. The ABTS/H2O2/HRP method is adopted as the ground for medical diagnosis. Experimental results demonstrate that the minimum concentration successfully detected for H2O2 is 1muM. The detection limit is one order of magnitude better than a traditional CMOS biosensor, and comparable to a commercial spectrophotometer.
Keywords :
CMOS integrated circuits; biomedical electronics; biosensors; hydrogen compounds; optical sensors; photodiodes; visible spectroscopy; CMOS biochip; CMOS-compatible optical biosensing system; H2O2; P+/Nwell finger photodiode; medical diagnosis; size 0.35 mum; transimpedance amplifier; visible absorption spectroscopy; Biomedical optical imaging; Biosensors; CMOS technology; Electromagnetic wave absorption; Fingers; Optical sensors; Photodiodes; Prototypes; Spectroscopy; Stimulated emission;
Conference_Titel :
Electron Devices and Solid-State Circuits, 2007. EDSSC 2007. IEEE Conference on
Conference_Location :
Tainan
Print_ISBN :
978-1-4244-0637-1
Electronic_ISBN :
978-1-4244-0637-1
DOI :
10.1109/EDSSC.2007.4450320
