A CMOS-Compatible Optical Biosensing System Based on Visible Absorption Spectroscopy

Author

Chang, Yu-Wei ; Yu, Ping-Chun ; Huang, Yang-Tung ; Yang, Yuh-Shyong

Author_Institution

Nat. Chiao Tung Univ., Hsinchu

fYear

2007

fDate

20-22 Dec. 2007

Firstpage

1099

Lastpage

1102

Abstract

A CMOS-compatible optical biosensing system based on visible absorption spectroscopy is proposed. Within the compact prototype, the CMOS sensor consisting a P⁺/N_well finger photodiode and a transimpedance amplifier (TIA) is implemented in a standard 0.35-mum CMOS technology. The ABTS/H₂O₂/HRP method is adopted as the ground for medical diagnosis. Experimental results demonstrate that the minimum concentration successfully detected for H₂O₂ is 1muM. The detection limit is one order of magnitude better than a traditional CMOS biosensor, and comparable to a commercial spectrophotometer.

Keywords

CMOS integrated circuits; biomedical electronics; biosensors; hydrogen compounds; optical sensors; photodiodes; visible spectroscopy; CMOS biochip; CMOS-compatible optical biosensing system; H₂O₂; P⁺/N_well finger photodiode; medical diagnosis; size 0.35 mum; transimpedance amplifier; visible absorption spectroscopy; Biomedical optical imaging; Biosensors; CMOS technology; Electromagnetic wave absorption; Fingers; Optical sensors; Photodiodes; Prototypes; Spectroscopy; Stimulated emission;

fLanguage

English

Publisher

ieee

Conference_Titel

Electron Devices and Solid-State Circuits, 2007. EDSSC 2007. IEEE Conference on

Conference_Location

Tainan

Print_ISBN

978-1-4244-0637-1

Electronic_ISBN

978-1-4244-0637-1

Type

conf

DOI

10.1109/EDSSC.2007.4450320

Filename

4450320