Title :
Applications of time-resolved fluorescence spectroscopy to atherosclerotic cardiovascular disease and brain tumors diagnosis
Author :
Marcu, Laura ; Jo, Javier A. ; Fang, Qiyin ; Papaiannou, Thanassis
Author_Institution :
Dept. of Surg., Cedars-Sinai Med. Center, Los Angeles, CA, USA
Abstract :
This paper presents the development of an apparatus and associated practical methodologies for time-resolved laser-induced fluorescence spectroscopy (TR-LIFS) of tissues that account for clinical needs and overcome some of the barriers that have limited its implementations in clinical settings. These include rapid fluorescence data acquisition with high temporal resolution and sensitivity within a broad range of emission wavelengths; rapid data processing, analysis and display; and compact and portable instrumentation.
Keywords :
bio-optics; brain; cancer; cardiovascular system; fluorescence; patient diagnosis; time resolved spectroscopy; tumours; atherosclerotic cardiovascular disease; brain tumors diagnosis; compact instrumentation; high temporal resolution; portable instrumentation; rapid data analysis; rapid data display; rapid data processing; rapid fluorescence data acquisition; time-resolved laser-induced fluorescence spectroscopy; tissues; Cardiovascular diseases; Fiber lasers; Fluorescence; Instruments; Neoplasms; Optical pulse generation; Pathology; Probes; Space vector pulse width modulation; Spectroscopy;
Conference_Titel :
Lasers and Electro-Optics, 2005. (CLEO). Conference on
Print_ISBN :
1-55752-795-4
DOI :
10.1109/CLEO.2005.202425
