Electronic dynamic cellular sensor used to measure gold nanoparticles enhanced radiotherapy

Author

Xing, James Z. ; Yang, Xiaoyan ; Chen, Jie ; Huang, Biao ; Roa, Wilson

Author_Institution

Dept. of Lab. Med. & Pathology, Univ. of Alberta, Edmonton, AB, Canada

fYear

2011

fDate

7-8 April 2011

Firstpage

20

Lastpage

23

Abstract

Conventional cellular test, such as clonogenic assay and MTT assay, can only be used to determine the cell effects at one certain time point and impossible for dynamic monitoring. Real time electronic cellular sensor (RT-CES) has been developed for real-time and dynamic cellular monitoring. In this paper, we described how to use RT-CES for real-time monitoring the dynamic change induced by the toxicants and radiotherapy. The gold nanoparticles enhanced radiotherapy was evaluated. Radiation therapy resistance was measured in real time and the dynamic data were used to guide radiotherapy on cancer cells in vitro.

Keywords

biomedical materials; biomedical measurement; biosensors; cancer; cellular biophysics; gold; nanomedicine; nanoparticles; radiation therapy; Au; RT-CES; cancer cells; electronic dynamic cellular sensor; gold nanoparticle enhanced radiotherapy; radiation therapy resistance; radiotherapy induced dynamic cell changes; real time dynamic cellular monitoring; real time electronic cellular sensor; toxicant induced dynamic cell changes; Cancer; Immune system; Monitoring; Nanoparticles; Real time systems; Resistance; Transient analysis;

fLanguage

English

Publisher

ieee

Conference_Titel

Life Science Systems and Applications Workshop (LiSSA), 2011 IEEE/NIH

Conference_Location

Bethesda, MD

Print_ISBN

978-1-4577-0421-5

Type

conf

DOI

10.1109/LISSA.2011.5754145

Filename

5754145